Although a database analysis study using the English National Health Service observed a U-shaped association between treated BP levels and all-cause mortality in older (≥80 years old) patients with hypertension, the higher mortality in the high systolic BP range might be due to the high incidence rate of cardiovascular events. ![]() Studies on nursing home residents older than 80 years old reported that individuals with low systolic blood pressure (<130 mmHg) with multiple BP medications had the highest mortality rate. The Berlin Initiative Study that included ≥70-year-old patients taking antihypertensive drugs found that, compared with non-normalized BP, normalized BP was associated with an increased risk of all-cause mortality in patients ≥80 years old, but not in aged 70–79 years old patients. A higher mortality rate in the normal BP range was also noted in observational studies of older patients with treated hypertension.
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